FoldX as Protein Engineering Tool: Better Than Random Based Approaches?

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Query-Based Sampling: Can we do Better than Random?

Many servers on the web offer content that is only accessible via a search interface. These are part of the deep web. Using conventional crawling to index the content of these remote servers is impossible without some form of cooperation. Query-based sampling provides an alternative to crawling requiring no cooperation beyond a basic search interface. In this approach, conventionally, random qu...

متن کامل

Protein engineering as a tool for crystallography.

The generation of large quantities of protein by overexpression technology has enabled structural studies of many important molecules that are found in only minute quantities in the cell. An increasing number of structures of proteins overexpressed in non-native systems have been solved. Crystallographers now have an extremely powerful tool, namely protein engineering, for the generation of nat...

متن کامل

Multiple Random Oracles Are Better Than One

We study the problem of learning k-juntas given access to examples drawn from a number of different product distributions. Thus we wish to learn a function f : {−1, 1}n → {−1, 1} that depends on k (unknown) coordinates. While the best known algorithms for the general problem of learning a k-junta require running time of n poly(n, 2), we show that given access to k different product distribution...

متن کامل

Evolutionary approaches to protein engineering.

1 Targets and Tasks for Protein Engineering . . . . . . . . . . . . . . . . . . 56 1.1 Folding . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 56 1.1.1 Thermodynamic Stability . . . . . . . . . . . . . . . . . . . . . . . . . 57 1.1.2 Thermal and Environmental Stability . . . . . . . . . . . . . . . . . . . . 57 1.1.3 Other Folding Considerations . . . . . . . . . . . . . . . . . ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Computational and Structural Biotechnology Journal

سال: 2018

ISSN: 2001-0370

DOI: 10.1016/j.csbj.2018.01.002